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Beta blockers: Concomitant use may inhibit bronchodilating effects. Severe bronchospasms may be produced in asthmatic patients taking salbutamol.
Methyldopa: Concurrent administration may result in an increased pressor response.
MAO inhibitors: Coadministration may result in severe headache, hypertension, and hyperpyrexia, resulting in hypertensive crisis. MAO inhibitors also potentiate the actions of beta-adrenergic agonists on the vascular system. Avoid coadministration with sympathomimetics or within 2 weeks.
Tricyclic antidepressants (TCAs): TCAs potentiate the pressor response of direct-acting sympathomimetics; dysrhythmias have occurred.
Theophylline: Enhanced toxicity, particularly cardiotoxicity, has been noted. Decreased theophylline levels may occur.
Diuretics: ECG changes and hypokalemia associated with these diuretics may worsen with coadministration.
Digoxin: Patients receiving such concomitant therapy may decrease in serum digoxin concentration. Carefully evaluated their serum digoxin concentration.
